Calcinosis Cutis Related to Sclerodermatous Chronic Graft Versus Host Disease

Calcinosis Cutis Related to Sclerodermatous Chronic Graft Versus Host Disease

We present the case of a 54-year-old woman who had calcinosis cutis related to sclerodermatous chronic graft versus host disease. Graft versus host disease had developed following stem cell transplantation for acute myelogenous leukemia 14 years earlier, but was shown by skin biopsy to have resolved by the time of presentation. Radiographs showed extensive cutaneous calcifications in the lower ...

Etretinate therapy for refractory sclerodermatous chronic graft-versus-host disease.

Chronic graft-versus-host disease (GVHD) is the most common late complication of allogeneic bone marrow transplantation (BMT). The sclerodermatous form of the disease is often refractory to standard treatment modalities. Based on reports of response to etretinate, a synthetic retinoid, among patients with scleroderma, we have added etretinate to the treatment regimen of 32 patients with refract...

Imatinib for sclerodermatous graft-versus-host disease in lung transplantation.

Imatinib has been proposed as a treatment for sclerodermatous chronic graft-versus-host disease (GVHD) due to its antifibrotic activity. Because imatinib has a potentially adverse effect on wound healing, the safety of its perioperative use in lung transplantation is unknown. Herein, we present a patient who underwent bilateral living-donor lobar lung transplantation for pulmonary complications ...

Sclerodermatous Graft-versus-Host Disease Arsenic Trioxide Prevents Murine

PReS-FINAL-2127: Sclerodermatous graft versus host disease

Results A 7 year old girl was referred to rheumatology 2 years after maternal HLA matched HSCT for acute lymphoblastic leukaemia. Mild cutaneous GVHD was noted post transplant. She subsequently presented with severe sclerodermatous changes on both lower legs. She had marked loss of range of movement (ROM) of her ankles, and the disease rapidly progressed to involve the skin of her thighs and le...